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Fluoxetine skeletal

Fluoxetine.

Fluoxetine, commonly known under the brand name Prozac, is an alkaloid that acts as a selective serotonin reuptake inhibitor (SSRI) antidepressant.

NorfluoxetineEdit

Norfluoxetine is the active metabolite of fluoxetine. Its pharmacological effects are essentially identical to fluoxetine but its potency is slightly lower.

Drug information
Fluoxetine pills
Fluoxetine
Brand name(s) Prozac
Class SSRI Antidepressant.
Common formulations Hydrochloride salt.
DrugBank ID DB00472.
Pharmacokinetics
Bioavailability 72%
peaks at 6-8 h
Protein binding 94.5%
Half life 1-3 days (initial), 4-6 days (chronic); Norfuoxetine (active metabolite) 4-16 days (acute & chronic).
Metabolism Hepatic (CYP2D6, CYP3A4).
Excretion Kidneys (80%), intestines (15%).
Therapeutic considerations
Typical dose 20mg
Pregnancy category C
Dependency liability Low
Side effects Nausea, insomnia, somnolence, anorexia, akathisia, anxiety, tremor, suicidal thoughts, reduced libido.
Routes of administration Oral
Legal status Rx only.